Description of the Incident of Fever and Local Pain Following Pentabio Immunization in Infants at the Integrated Health Post (Posyandu) at the Timpah Community Health Center, Central Kalimantan

Authors

  • Fanita Oktavia Institut Teknologi, Sains, dan Kesehatan RS.DR. Soepraoen Kesdam V/BRW

DOI:

https://doi.org/10.57214/jasira.v3i2.322

Keywords:

Adverse Events, Fever, Infant, Immunization, Local Pain

Abstract

Immunization is a vital public health strategy to prevent infectious diseases and reduce morbidity and mortality. In Indonesia, the Pentabio vaccine protects against diphtheria, pertussis, tetanus, hepatitis B, and Haemophilus influenzae type b. Despite its effectiveness, post-immunization reactions such as fever and local pain are common, potentially affecting caregiver perceptions and immunization adherence. A descriptive observational study with a cross-sectional design was conducted among infants receiving Pentabio immunization at Posyandu in the UPT Timpah Community Health Center, Central Kalimantan. Data were collected through structured observation and caregiver interviews for infants aged 2–11 months. Fever (≥37.5°C) and local pain (tenderness, redness, or swelling) were assessed. Of the 30 infants, 40% were aged 2–3 months, 33.33% were 4–6 months, and 26.67% were 7–11 months, with slightly more males (53.33%). Post-immunization fever occurred in 60%, and local pain in 70%, with both reactions being mild, transient, and appearing within 24–48 hours. These findings highlight the commonality of mild adverse events, especially in early infancy, and underscore the need for clear caregiver education to maintain confidence in immunization services and ensure adherence to vaccination schedules.

References

Aherkar, R. Y., Deshpande, P. K., & Ghongane, B. B. (2021). Epidemiological study of adverse events following immunization in children under 5 years. Journal of Family Medicine and Primary Care, 10(7). https://doi.org/10.4103/jfmpc.jfmpc_1582_21

Flanagan, K. L., Fink, A. L., Plebanski, M., & Klein, S. L. (2017). Sex and gender differences in the outcomes of vaccination over the life course. Annual Review of Cell and Developmental Biology, 33, 577–599. https://doi.org/10.1146/annurev-cellbio-100616-060530

Hervé, C., Laupèze, B., Del Giudice, G., Didierlaurent, A. M., & Tavares Da Silva, F. (2019). The how’s and what’s of vaccine reactogenicity. NPJ Vaccines, 4(1), 39. https://doi.org/10.1038/s41541-019-0092-6

Hidayati, C., Wati, D. P., & Nurhidayah, L. (2020). Adverse events following immunization (AEFI) profile of Pentabio vaccine in infants: A community-based cross-sectional study. Journal of Preventive Medicine and Public Health, 53(4), 289–296. https://doi.org/10.3961/jpmph.20.131

Kementerian Kesehatan RI. (2020). Pedoman imunisasi dasar lengkap. Kementerian Kesehatan RI.

Klein, S. L., & Flanagan, K. L. (2016). Sex differences in immune responses. Nature Reviews Immunology, 16(10), 626–638. https://doi.org/10.1038/nri.2016.90

Mittal, S., Rawat, C., Gupta, A., Solanki, H. K., & Singh, R. K. (2023). Adverse events following immunization among children under two years of age: A prospective observational study from North India. Cureus, 15(4), e38356. https://doi.org/10.7759/cureus.38356

Owais, A., Hameed, A., & Siddiqui, A. (2020). Side effects and safety profile of pentavalent vaccine among infants: A community-based survey. Vaccine Development and Therapy, 10, 11–20. https://doi.org/10.2147/vdt.s323485

Pan, X., Hu, Y., Chen, F., Lv, H., Wang, Y., & Liang, H. (2021). Analysis of adverse events following immunization in Zhejiang, China: A retrospective cross-sectional study based on the passive surveillance system. Human Vaccines & Immunotherapeutics, 17(10), 3823–3830. https://doi.org/10.1080/21645515.2021.1924650

Pan, X., Lv, H., Liang, H., Wang, Y., Shen, L., Chen, F., & Hu, Y. (2022). Surveillance on the adverse events following immunization with the pentavalent vaccine in Zhejiang, China. Human Vaccines & Immunotherapeutics, 18(1), 2021711. https://doi.org/10.1080/21645515.2021.2021711

Pulendran, B., Li, S., & Nakaya, H. I. (2021). Systems vaccinology. Immunity, 53(6), 887–905. https://doi.org/10.1016/j.immuni.2020.11.004

Restu, N. K., Sari, R. M., & Prasetyo, D. (2021). Factors influencing early immunization uptake: Evidence from rural community health posts. Global Health Research and Policy, 6(23). https://doi.org/10.1186/s41256-021-00226-7

Sari, D. R., Hamid, A. R., & Utami, D. S. (2019). Post-immunization reactions of Pentabio vaccine in infants at community health centers in Indonesia. Indonesian Journal of Child Health, 7(3), 112–120. https://doi.org/10.24235/ijch.v7i3.1250

Sharma, R., Sharma, B., Saini, Y., Bairwa, R., & Kakkar, M. (2025). Adverse events following pentavalent vaccine administration: A descriptive study in the Indian context. Journal of Berk Epidemiology, 13(2), 112–117. https://doi.org/10.1169/jbe.2025.0211

Siegrist, C. (2018). Vaccine immunology. In Vaccine (7th ed., pp. 16–34). Elsevier. https://doi.org/10.1016/B978-0-323-46900-6.00002-5

Sundoro, J., Prayitno, A., Satari, H. I., Djelantik, I. G., Fletcher, M. A., & Hadinegoro, S. R. (2024). Safety of a 2-dose primary series of 13-valent pneumococcal conjugate vaccine in Indonesian infants. Medical Journal of Indonesia.

World Health Organization (WHO). (2019). WHO vaccine safety basics training: Module 2 – How vaccines work [Internet]. WHO Press. Available from:

World Health Organization (WHO). (2020). Immunization in practice: A practical resource guide for health staff (4th ed.). WHO Press.

Wulandari, Y., Putri, A. M., & Firdaus, E. (2022). Incidence and management of common adverse events following Pentabio immunization in infants. Journal of Tropical Plant Science, 68(2). https://doi.org/10.20886/jtps.2022.68.2.1002

Downloads

Published

2026-04-16

How to Cite

Fanita Oktavia. (2026). Description of the Incident of Fever and Local Pain Following Pentabio Immunization in Infants at the Integrated Health Post (Posyandu) at the Timpah Community Health Center, Central Kalimantan. Jurnal Siti Rufaidah, 3(2), 68–81. https://doi.org/10.57214/jasira.v3i2.322

Similar Articles

<< < 1 2 3 4 

You may also start an advanced similarity search for this article.